Cocrystallization of urea and succinic acid in “Nano-Crystallizer”

نویسندگان

چکیده

In the bulk scale of crystallization, urea-succinic acid (U-SA) cocrystals have been reported to only form stable 2:1 U-SA cocrystal, without any metastable 1:1 by slow evaporation and cooling crystallization in an aqueous solvent. this work, were applied nano-crystallizers, i.e. nano-pores controlled pore glass (CPG). It is first time demonstrate that, with confined solution, it possible produce maintain during process, indicating strong influences confinement on phase diagram thermodynamic properties nano-scale cocrystals. The urea succinic concentration size CPG polymorphs melting point nanocrystal investigated. Further understanding mechanism may contribute new methods for maintaining unstable materials discovering forms pharmaceutical compounds materials.

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ژورنال

عنوان ژورنال: Chemical Engineering Science

سال: 2021

ISSN: ['1873-4405', '0009-2509']

DOI: https://doi.org/10.1016/j.ces.2020.116082